| PICO 1 | In adult patients diagnosed with acute bronchitis and symptoms associated with persistent wheezing, does adding inhaled corticosteroids instead of bronchodilator therapy alone improve symptoms and reduce the duration of a cough? |
| PICO 2 | In adults with uncomplicated skin abscesses undergoing incision and drainage, does adjunctive oral antibiotic therapy compared to incision and drainage alone improve clinical cure rates? |
| PICO 3 | In adults with a persistent H.Pylori infection after treatment failure with clarithromycin-based triple therapy, does bismuth- based quadruple therapy, compared to second-line regimens (e.g., levofloxacin-based triple therapy), result in higher rates of eradication? |
| PICO 4 | In adult patients presenting with herpes zoster, do antivirals valacyclovir or famciclovir, in comparison to acyclovir, decrease the pain associated with this condition, along with the incidence of postherpetic neuralgia as a complication? |
| PICO 5 | In patients with vaginal foreign bodies, does ultrasound, compared to radiography, improve diagnostic accuracy? |
| PICO 6 | In adults presenting to the emergency department with acute renal colic, does IV ketorolac compared to IV opioids provide equivalent or superior pain relief with fewer adverse effects? |
| Draft Mini- CAT | For homeless adults discharged from the hospital after an acute illness, does placement in a medical respite program, compared to discharge to a shelter or the street, reduce 30-day hospital readmission rates? |
| Final Mini- CAT | For homeless adults discharged from the hospital after an acute illness, does placement in a medical respite program, compared to discharge to a shelter or the street, reduce 30-day hospital readmission rates? |
| PICO 7 | For elderly patients with fractures, do multifactorial fall-prevention programs combining exercise, medication review, and environmental modifications reduce fall recurrence and improve functional independence compared with single-intervention approaches such as assistive devices alone? |
| PICO 8 | In adult patients with PEG tubes, does scheduled prophylactic PEG tube replacement compared with replacement after tube malfunction reduce PEG-related complications and emergency department visits? |
| PICO 9 | In elderly postoperative patients with intra-abdominal or pelvic collections, does oral step-down antibiotic therapy compared with prolonged intravenous antibiotic therapy result in similar infection resolution and readmission rates? |
